Real Americans begins on the precipice of Y2K in New York City, when twenty-two-year-old Lily Chen, an unpaid intern at a slick media company, meets Matthew. Matthew is everything Lily is not: easygoing and effortlessly attractive, a native East Coaster, and, most notably, heir to a vast pharmaceutical empire. Lily couldn't be more different: flat-broke, raised in Tampa, the only child of scientists who fled Mao’s Cultural Revolution. Despite all this, Lily and Matthew fall in love.

In 2021, fifteen-year-old Nick Chen has never felt like he belonged on the isolated Washington island where he lives with his single mother, Lily. He can't shake the sense she's hiding something. When Nick sets out to find his biological father, the journey threatens to raise more questions than it provides answers.